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For anyone whose sleep problems stem partly from stress, this mechanism matters enormously

However, sustained high levels of CORT override these protective responses one by one, favoring pathways leading to injury, such as apoptosis signaling triggered by NRPL3, inadequate synthesis of ROS decomposition, nuclear accumulation of FOXO3a, and sustained activation of the Notch pathway and ERS-IRE1/XBP1 signaling pathway, all contributing to cell death

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Association between serum concentrations of persistent organic pollutants and prevalence of newly diagnosed hypertension: results from the National Health and Nutrition Examination Survey 1999-2002

Real-world experience from clinical programs and observational cohorts reinforce trial data and demonstrate more heterogeneity

10.1186/s12964-023-01041-3 15 HangS.WuW.WangY.ShengR.FangY.GuoR